Large-scale brain network dynamics supporting adolescent cognitive control

DB Dwyer; BJ Harrison; M Yücel; S Whittle; A Zalesky; C Pantelis; NB Allen; A Fornito

Journal article

Large-scale brain network dynamics supporting adolescent cognitive control

DB Dwyer, BJ Harrison, M Yücel, S Whittle, A Zalesky, C Pantelis, NB Allen, A Fornito

Journal of Neuroscience | Published : 2014

DOI: 10.1523/JNEUROSCI.1634-14.2014

Abstract

Adolescenceisatime when the ability to engage cognitive controlislinked to crucial life outcomes. Despiteahistorical focus onprefrontal cortex functioning, recent evidence suggests that differences between individuals may relate to interactions between distributed brain regions that collectively form a cognitive control network (CCN). Other research points to a spatially distinct and functionally antagonistic system—the default-mode network (DMN)—which typically deactivates during performance of control tasks. This literature implies that individual differences in cognitive control are determined either by activation or functional connectivity of CCN regions, deactivation or functional conne..

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University of Melbourne Researchers

Dom Dwyer Author

Ben Harrison Author

Sarah Whittle Author

Andrew Zalesky Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council

Awarded by NHMRC

Awarded by Australian Research Council Future Fellowship

Awarded by NHMRC Clinical Career Development Fellowship

Awarded by NHMRC Career Development Fellowships

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Senior Principal Research Fellowship

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia, Program Grant 350241), and the Australian Research Council (Discovery grants DP0878136 and DP1092637). A.F. was supported by an NHMRC grant (1050504) and an Australian Research Council Future Fellowship (FT130100589). B.J.H. was supported by an NHMRC Clinical Career Development Fellowship (628509). S.W. and A.Z. were supported by NHMRC Career Development Fellowships (1007716 to S.W.; 1047648 to A.Z.). M.Y. was supported by an NHMRC Senior Research Fellowship (1021973). C.P. was supported by an NHMRC Senior Principal Research Fellowship (628386). We also thank the Royal Children's Hospital for assistance with acquiring the imaging data and the families for participating in the study.